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Fusions involving known oncogenes often retain functional domains and are "in-frame," supporting their role in cancer, as noted in the Nature Communications study .

Genetic fusions favor tumorigenesis through degron loss in oncogenes 24336.rar

Specific recurrent fusions validated included BCR-ABL, CCDC6-RET, and PML-RARA. " supporting their role in cancer

9,624 tumor samples from TCGA, investigating degron loss (a mechanism that stabilizes proteins, encouraging cancer growth). Key Findings: and PML-RARA. 9

This research suggests that degron loss is a general mechanism in tumorigenesis, similar to promoter swapping, as shown in the study's PDF document .