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: Should be avoided unless a strict benefit/risk assessment justifies it.

: This is the primary reference guide used by healthcare professionals to identify absolute contraindications (CI), associations to be avoided (ASDEC), and precautions for use. : Should be avoided unless a strict benefit/risk

: An online portal that allows you to download the most recent PDF updates and search for specific drug pairs. Understanding the 4 Severity Levels associations to be avoided (ASDEC)

: The association is possible provided that specific recommendations (e.g., monitoring, dosage adjustment) are followed. : Should be avoided unless a strict benefit/risk

The "Contraindicated" level is the highest of the four official clinical severity grades and has an absolute character; it must not be transgressed due to frequent and severe clinical consequences. Essential Official Documents