Gigp-40.mp4

The enzyme PYGL-1 is necessary for this metabolic flexibility.

Glycogen supports glycolytic plasticity in neurons - PMC - NIH GIGP-40.mp4

Glycogen serves as a direct fuel source to sustain glycolytic plasticity and synaptic function in vivo. The inability to utilize GDGP is associated with deficiencies in synaptic vesicle recycling during hypoxia. The enzyme PYGL-1 is necessary for this metabolic

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Traditionally, neurons were thought to rely primarily on blood-glucose-derived glucose, with astrocytes managing glycogen storage. However, evidence now indicates that neurons can engage in their own glycogen-dependent glycolytic plasticity (GDGP) to meet sudden metabolic demands. This paper investigates how GDGP operates, specifically in mitigating the effects of mitochondrial dysfunction. Findings on GDGP Mechanisms

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