Greys Anatomy - Season 12 May 2026

Season 12 of Grey's Anatomy , which premiered on September 24, 2015, is often described as the "season of rebirth". Following the death of Derek Shepherd in Season 11, the show shifted to a noticeably lighter, more "rom-com" tone, reminiscent of its earliest seasons.

: Alex proposes multiple times, but Jo repeatedly declines because she is secretly still married to an abusive man she fled years prior. Cast Transitions Greys Anatomy - Season 12

: Their developing romance culminates in a wedding in the season finale, though Amelia initially has doubts and runs away before the ceremony. Season 12 of Grey's Anatomy , which premiered