[s4e2] Love/addiction -

Meredith's half-sister, Lexie, attempts to bond with Meredith, who remains resistant to having a relationship with her.

Watch a recap of the episode's themes and major character developments here: [S4E2] Love/Addiction

George struggles with his guilt after admitting he loves Izzie, while Callie, as Chief Resident, is overwhelmed by her duties and her suspicions that George is cheating. Alex Karev deals with a particularly difficult case

The residents and interns treat victims of a massive apartment fire caused by a meth lab explosion. Alex Karev deals with a particularly difficult case involving a baby who suffered a stroke due to the meth lab environment. attempts to bond with Meredith

The episode explores various forms of "addiction"—from chemical dependency to toxic emotional attachments—as the staff at Seattle Grace Hospital treats victims of a massive apartment explosion. Main Plotlines