: Likely represents the first variable or a specific variant in a ranked list of potential regulatory interactions.
: Likely refers to the EAGLE tool or its associated database, EnhancerAtlas . theagle.Cely.1.var
The physical distance between the enhancer and the gene's transcription start site. : Likely represents the first variable or a
: This often denotes cell-type specificity , a core feature of EAGLE which allows it to distinguish between interactions that only occur in certain tissues. : This often denotes cell-type specificity , a
The most interesting aspect of variables in this system is their ; unlike older models that required dozens of inputs, EAGLE uses only six core features to predict interactions with high accuracy:
These track the number of other enhancers (EWS) or genes (GWS) located in the "window" between the enhancer and gene of interest, accounting for potential interference or competition.