The second season, which premiered on September 27, 2007, consists of 18 episodes. It picks up three weeks after the Season 1 finale with several characters in crisis:

: Hilda struggles to accept the death of Santos, while Ignacio remains in Mexico trying to secure a visa.

: Wilhelmina Slater uses the absence of the Meades to tighten her grip on the magazine, plotting her marriage to Bradford Meade. Key Storylines & Highlights

: Daniel recovers from a car crash while his sister Alexis awakens with amnesia, forgetting her transition and believing she is still "Alex".